Re: ORGLIST: Deprotection of a trityl group

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From: Maringanti Krishna (maringanti9$##$yahoo.com)
Date: Fri Dec 17 2004 - 00:19:22 EST


Ken:
Did you try HCl in non-aqueous solvents? Usually you can knock off a trityl group with HCl in dioxane, reflux briefly. If there is solubility problem, you could try HCl in EtOH/MeOH or sometimes better HBr in acetic acid! You need to choose a condition where work up and isolation are very easy and obvious! Trityl/pivalyl groups cannot survive acid for sure!
Cheers!
Krishna
 

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