From: Andrea Giordano (giordano$##$embl.de)
Date: Wed Dec 15 2004 - 05:44:33 EST
gamma-carboxyglutamate is commonly found as a post-translational modified
component of protein factors responsible for the blood clotting cascade, and
it acts as a Ca chelator, upon which coagulation factors are activated.
I was wondering whether a chemical synthesis of this glutamate was feasible
(is it stable outside biological environment?) in such a form that allows
further manipulation, like incorporation into peptides.
Which is the coordination geometry of the Ca ion and the carboxylic residues?
How many COOH groups are bound per Ca ion?
Are there any other Ca chelators (apart from EDTA and EGTA) that may have same
Hope i raised some interest.... :-)
Thanks a lot!
-- Andrea Giordano, PhD student Schultz group (Bioorganic chemistry of signaling molecules) http://www-db.embl-heidelberg.de/jss/emblGroups/g_162.html Gene Expression Program European Molecular Biology Laboratory Meyerhofstrasse, 1 69117 Heidelberg, Germany tel: 0049 6221 387 -498 (chem. lab) -264 (mol.bio. lab) fax: 0049 6221 387 206 _______________________________________________ ORGLIST - Organic Chemistry Mailing List Website / Archive / FAQ: http://www.orglist.net To post a message (TO EVERYBODY) send to everybody$##$orglist.net To unsubscribe, send to everybody-request$##$orglist.net the message: unsubscribe your_orglist_password your_address List coordinator: Joao Aires de Sousa (coordinator$##$orglist.net)
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