ORGLIST:post doctoral position

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From: pierre-yves renard (pierre-yves.renard$##$univ-rouen.fr)
Date: Fri Sep 10 2004 - 10:06:29 EDT


SYNTHESIS OF A CHEMILUMINESCENT PROBE FOR THE DETECTION OF A PROTEOLYTIC ACTIVITY
 
novembre 2004- novembre 2005
 
IRCOF de Rouen, UMR CNRS 6014,  laboratoire d’hétérochimie organique,
 équipe de chimie bioorganique. Rue Tesnière F-76131 MONT St AIGNAN
FRANCE
 
Contact : Pr. Pierre-Yves RENARD
pierre-yves.renard@univ-rouen.fr
phone : + 33 2 35 52 24 14.
 
This post doctoral position is part of a collaboration between our laboratory, and QUIDD (QUantitative Imaging for Drug Discovery), a French start up aimed at the in vivo evaluation of drugs effects via small animal imaging. The aim is to design, synthesise and evaluate a new chemiluminescent probe for the in vivo detection of a targeted proteolytic activity. The synthesis strategy will be based on our previously described work on 1,2-dioxetane chemiluminescent probes for the detection of esterase activities.1
 
Funding : QUIDD.
Duration : one year as from fall 2004.
Profile : Non French citizen with PhD thesis in organic synthesis, with a specific interest at the chemistry-biology interface.
 


1 Design and synthesis of chemiluminescent probes for the detection of Cholinesterase activity S. Sabelle, P.Y. Renard,* K. Pecorella, S. de Suzzoni-Dezard, C. Créminon, J. Grassi, C. Mioskowski  J. Am. Chem. Soc (2002), 124(17), 4874-4880. McMurry intermolecular cross-coupling between an ester and a ketone. Scope and limitation. S.Sabelle, J. Hydrio, E. Leclerc, C. Mioskowski, P.Y. Renard* Tetrahedron Lett. (2002), 43 (20), 3645-3648

Pr. Pierre-Yves Renard
IRCOF-LHO
UMR CNRS 6014
1, rue Henri Tesnières
F-76131 Mont St Aignan Cedex

+ 33 2 35 52 24 14
+ 33 2 35 52 29 59 (fax)
pierre-yves.renard@univ-rouen.fr
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