ORGLIST:Protecting OH; Methoxymethyl acetate versus methoxymethyl chloride

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From: =?ISO-8859-2?Q?Jerzy Kr=F3l-Bogomilski Ph.D.?= (jerzy.krol$##$
Date: Sun May 02 2004 - 15:14:01 EDT

Dear members,

Sometimes you need to protect an OH group of alcohol and phenol.
Methoxymethyl chloride is often used in such cases.

However, there is other alternative to use. It is methoxymethyl acetate. It protects alcohols and phenols under very mild conditions. Your yield might be much better, too.

Some years ago I published a paper:

"On reactivity of methoxymethyl acetate towards alcohols and
phenols", J. Krol, G. Grynkiewicz, A. Kutner, Polish J. Chem.,
65, 1433, (1991).

See my web page:

You can also read the full paper at:

Yours sincerely,

Jerzy Król-Bogomilski Ph. D. -
Sodium bicarbonate industrial environmentally
friendly production with no wastes, 100% water
is recycled and remains in circulation.
The scientific discovery is mentioned in Encyclopedia
Britannica and is patented. Click to Recommend-It
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