ORGLIST: Structure of Cyprodime and Naltrindol

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From: Eric J. Leopold (ejlmp$##$earthlink.net)
Date: Fri Jan 12 2001 - 22:08:32 EST


One of these articles should have a structure.
The structure name of Cyprodime is
(-)-17-(Cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one from the title of
ref. 4 below.
1. Synthesis of Tritiated N1'-Alkyl Derivatives of the Delta Opioid Recepto=
r
Ligand Naltrindole
John R. Lever; Suzanne M. Johanson

J.Labelled Compd.Radiopharm. 1997, 39 : 2 115-122.

2. Opioid Affinity and Selectivity of 4-Hydroxy-3-methoxyindolomorphinan
Analogues Related to Naltrindole
Andrew Coop; Richard B. Rothman; Christina Dersch; John Partilla; Frank
Porreca; et al.
J.Med.Chem. 1999, 42 : 9 1673 - 1679

3. Synthesis, Opioid Receptor Binding, and Bioassay of Naltrindole Analogue=
s
Substituted in the Idolic Benzene Moiety
Subramaniam Ananthan; Cheryl A. Johnson; Ronald L. Carter; Sarah D. Clayton=
;
Kenner C. Rice; et al.
J.Med.Chem. 1998, 41 : 15 2872-2881

Here's the structure
4. Tritium Labelling of Cyprodime
(=(-)-17-(Cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one), a ΅
Receptor-Selective Opioid Antagonist
Ferenc Oetvoes; Geza Toth; Helmut Schmidhammer

5. Synthesis and Biological Evaluation of 14-Alkoxymorphinans. 3. Extensive
Study on Cyprodime-Related Compounds
Helmut Schmidhammer; Colin F. C. Smith; Daniela Erlach; Martin Koch; Roland
Krassnig; et al.
J.Med.Chem. 1990, 33 : 4 1200-1206

6.SYNTHESIS AND BIOLOGICAL EVALUATION OF 14-ALKOXYMORPHINANS. 16. 14-O-ALKY=
L
DERIVATIVES OF THE ΅ OPIOID RECEPTOR ANTAGONIST CYPRODIME
Helmut Schmidhammer; Roland Krassnig; Elisabeth Greiner; John R. Traynor
Heterocycles 1998, 49 : 1 489 - 498

Good luck.
Eric J. Leopold
Pet your dog instead:
http://home.earthlink.net/~ejlmp/Maggie.html
Latitude 37n34, longitude (-)122w19, California







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